{"id":702,"date":"2021-11-15T16:23:04","date_gmt":"2021-11-15T15:23:04","guid":{"rendered":"https:\/\/portale.unime.it\/modelloricerca\/?page_id=702"},"modified":"2026-01-12T10:55:47","modified_gmt":"2026-01-12T09:55:47","slug":"ricerca-2","status":"publish","type":"page","link":"https:\/\/portale2.unime.it\/hanain\/?page_id=702","title":{"rendered":"RICERCA"},"content":{"rendered":"\t\t
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RICERCA


<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Il progetto interdisciplinare HANAIN coinvolge ricercatori che svolgono la loro attivit\u00e0 nei laboratori di ricerca di Chimica Farmaceutica e Microbiologia <\/h5>\t\t\t\t<\/div>\n\t\t\t\t
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Dipartimento <\/span>Scienze  Chimiche, Biologiche, Farmaceutiche ed Ambientali dell'Universit\u00e0 degli Studi di Messina<\/span> <\/span><\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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<\/span>Dipartimento di Medicina Sperimentale dell'Universit\u00e0 del Salento<\/a><\/h3>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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WORKPLAN<\/h3>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPharmacophore modelling\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tSviluppo di modelli farmacoforici Structure- e Ligand-based \nWP2-UNIME MEDCHEM LAB task 1\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVirtual Screening\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tRiposizionamento di molecole attive e hit optimization con procedure sintetiche innovative ed eco-friendly\nWP2-UNIME MEDCHEM LAB task 2-3\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStudi Biologici.1\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h4>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t

\n\t\t\t\t\t\tValutazione in vitro dell'attivit\u00e0 citotossica degli hit compounds \n\nWP3-UNIME \/ UNISALENTO VIROLAB task 1\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\tValutazione in vitro dell'attivit\u00e0 antivirale degli hit compounds mediante saggi specifici, ottimizzati e privi di virus infettivi.\nWP3-UNIME MEDCHEM LAB task 2\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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RICERCHE <\/h3>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Questa proposta progettuale \u00a0si avvier\u00e0 con studi in silico, che comprendono cicli di Virtual Screening\u00a0 Structure-Based e Ligand-Based \u00a0per la selezione di “small molecules” \u00a0candidate ad essere valuate quali inibitori di HA e NA.<\/span><\/span><\/span><\/p>

Le molecole selezionate (hit compounds) saranno testati per la loro capacit\u00e0 di esercitare effetti antivirali in assenza di citotossicit\u00e0 cellulare\u00a0<\/span><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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UNIME - MEDCHEM LAB <\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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Studi computazionali, virtual screening e hit optimization<\/b><\/h4>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Generazione del modello farmacoforico di interazione con HA e NA <\/span>
Screening delle librerie virtuali, docking e dinamiche molecolari, predizione delle propriet\u00e0 drug-like. <\/span><\/h3>

Approcci sintetici e determinazione sperimentale di propriet\u00e0 chimico-fisiche\u200b<\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sviluppo dei modelli i farmacoforici attraverso il software LigandScout di Inteligand che consente di creare diversi modelli farmacoforici basati sulla struttura e\/o sul ligando, definendo i gruppi funzionali complementari essenziali che possono essere condivisi dai ligandi proteici. Le strutture cristalline di complessi disponibili nel database PDB forniscono informazioni dettagliate sulle interazioni di legame dei complessi binari tra NA o HA e i loro rispettivi inibitori. Grazie ai modelli farmacoforici vengono eseguiti screening virtuali in banche dati di small molecules (composti di sintesi, composti naturali e farmaci attualmente in terapia), che una volta selezionate vanno in contro a processi \u00a0di docking molecolare e simulazioni dinamiche. Si impiegano programmi come Glide, Gold, Autodock e Desmond. La predizione in silico delle propriet\u00e0 fisico-chimiche e ADME (solubilit\u00e0, lipofilia, permeabilit\u00e0 cellulare e cos\u00ec via), calcolata in silico tramite il software Percepta ACD\/Lab, \u00e8 preliminare ai saggi biologici.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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UNIME \/ UNISALENTO VIROLAB<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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Laboratorio di Virologia dell\u2019Universit\u00e0 di Messina<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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Attivit\u00e0 di ricerca sui meccanismi molecolari che regolano le interazioni virus\u2013cellula ospite, con particolare attenzione alle infezioni da herpesvirus e retrovirus umani. Le nostre linee di ricerca esplorano il ruolo di NF-\u03baB, infiammazione, ROS, morte cellulare regolata e microRNA, e includono l\u2019identificazione e la validazione di molecole naturali o\u00a0 di nuova sintesi con potenziale attivit\u00e0 antivirale o antitumorale.\u00a0<\/p>

Il laboratorio sviluppa e ottimizza saggi funzionali innovativi per la
valutazione in vitro di composti bioattivi ed \u00e8 dotato di strumentazioni avanzate per analisi molecolari e studi cellulari.\u00a0<\/p>

Il gruppo di\u00a0 ricerca \u00e8 composto da una ricercatrice, da assegnisti e studenti che\u00a0 combinano competenze multidisciplinari in virologia, biologia\u00a0 molecolare, farmacologia e biotecnologie.\u00a0<\/p>

L\u2019attivit\u00e0 scientifica si\u00a0 svolge in un ambiente collaborativo e integrato in reti di ricerca nazionali e internazionali, con l\u2019obiettivo di produrre conoscenza e\u00a0 formazione qualificata.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Evento pubblico<\/span><\/b><\/u><\/p>\n

Kick-off Meeting per il lancio del progetto<\/em><\/span> HANAIN<\/strong><\/span><\/span><\/p>\n


<\/strong><\/span><\/span><\/p>

 <\/strong><\/span><\/span><\/p>\n

Aula A-1-6<\/strong><\/span><\/p>

ore 11.00<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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RICERCA Il progetto interdisciplinare HANAIN coinvolge ricercatori che svolgono la loro attivit\u00e0 nei laboratori di ricerca di Chimica Farmaceutica e Microbiologia Dipartimento Scienze  Chimiche, Biologiche, Farmaceutiche ed Ambientali dell’Universit\u00e0 degli Studi di Messina Dipartimento di Medicina Sperimentale dell’Universit\u00e0 del Salento WORKPLAN Pharmacophore modelling Sviluppo di modelli farmacoforici Structure- e Ligand-based WP2-UNIME MEDCHEM LAB task 1… Continua a leggere RICERCA<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-702","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nRICERCA - HANAIN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/portale2.unime.it\/hanain\/?page_id=702\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RICERCA - 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