This summer school proposes a new approach to the design and programming of CPSs by considering them as complex “systems of systems'' that need a specific methodology for their design and management. Better to say, all current systems are seen as CPS by nature and for this reason the interaction among the physical and the cyber parts has to be managed since the very first phases of their design. The IoT dimension is part of the overall infrastructure and IoT resources have to be considered since the very beginning, and kept at the same level of consideration of other more traditional resources such as computing, storage and networking. The school will teach how to design a network architecture with all the virtualized resources in place, how to optimise their interaction and keep everything under the full control of the system manager.