{"id":568,"date":"2019-02-18T08:37:54","date_gmt":"2019-02-18T07:37:54","guid":{"rendered":"http:\/\/portale.unime.it\/tmau-messina\/?page_id=2"},"modified":"2019-02-18T08:37:54","modified_gmt":"2019-02-18T07:37:54","slug":"tmau-cosa","status":"publish","type":"page","link":"https:\/\/portale2.unime.it\/tmaumessina\/tmau-cosa\/","title":{"rendered":"Cos&#8217;\u00e8 la TMAU"},"content":{"rendered":"<p style=\"text-align: justify;padding-left: 40px\"><span style=\"font-size: 14pt\">La trimetilaminuria (<strong>TMAU<\/strong>), nota anche come &#8220;sindrome dell&#8217;odore di pesce&#8221;, \u00e8 un disordine metabolico che comporta l&#8217;emissione di un forte e sgradevole odore paragonabile a quello del pesce marcio.<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 40px\"><span style=\"font-size: 14pt\">La sindrome \u00e8 dovuta all\u2019alterazione nel metabolismo della trimetilammina (TMA), un\u2019ammina terziaria maleodorante, normalmente ossidata dalla monoossigenasi-3 contenente la flavina (FMO3) in trimetilammina-N-ossido (TMAO), inodore.<\/span><br \/>\n<span style=\"font-size: 14pt\">La trimetilammina si accumula nell&#8217;organismo a causa della mancata trasformazione e viene emessa all&#8217;esterno tramite le urine, il sudore, il respiro, la saliva e le secrezioni vaginali.<\/span><\/p>\n<p style=\"text-align: center\"><strong><span style=\"font-size: 14pt\">Approfondimenti Bibliografici<\/span><\/strong><\/p>\n<ul style=\"list-style-type: square\">\n<li style=\"text-align: justify\">Chhibber-Goel J, Gaur A, Singhal V, Parakh N, Bhargava B, Sharma A. T<strong>he complexmetabolism of trimethylamine in humans: endogenous and exogenous sources<\/strong>. <em>Expert Rev Mol Med.<\/em> 2016 Apr 29;18:e8. doi: 10.1017\/erm.2016.6.<\/li>\n<li style=\"text-align: justify\">Fennema D, Phillips IR, Shephard EA.\u00a0<strong>Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3) &#8211; Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease<\/strong>. <em>Drug MetabDispos<\/em>. 2016 Nov;44(11):1839-1850. Epub 2016 May 17.<\/li>\n<li style=\"text-align: justify\">Esposito T, Varriale B, D&#8217;Angelo R, Amato A, Sidoti A. <strong>Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans<\/strong>. <em>Horm Mol Biol Clin Investig<\/em>. 2014 Dec;20(3):99-109. doi: 10.1515\/hmbci-2014-0012.<\/li>\n<li style=\"text-align: justify\">Motika MS, Zhang J, Zheng X, Riedler K, Cashman JR. <strong>Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19321370\">. <\/a><em>Mol Genet Metab<\/em>. 2009 Jun;97(2):128-35. doi: 10.1016\/j.ymgme.2009.02.006.<\/li>\n<li style=\"text-align: justify\">D&#8217;Angelo R, Esposito T, Calabr\u00f2 M, Rinaldi C, Robledo R, Varriale B, Sidoti A.<strong> FMO3 allelicvariants in Sicilian and Sardinianpopulations: trimethylaminuria and absence of fish-like body odor<\/strong>. <em>Gene<\/em>. 2013 Feb 25;515(2):410-5. doi: 10.1016\/j.gene.2012.12.047<\/li>\n<li style=\"text-align: justify\">D&#8217;Angelo R, Scimone C, Esposito T, Bruschetta D, Rinaldi C, Ruggeri A, Sidoti A. <strong>Fish odor syndrome (trimethylaminuria) supporting the possible FMO3 down expression in childhood: a case report<\/strong>. <em>J Med Case Rep<\/em>. 2014 Oct 6;8:328. doi: 10.1186\/1752-1947-8-328<\/li>\n<li style=\"text-align: justify\">Chalmers RA, Bain MD, Michelakakis H et al. <strong>Diagnosis and management of trimethylaminuria (FM03 deficiency) in children<\/strong>. <em>J Inherit Metab Dis<\/em>. 2006;29(1):162-72.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>La trimetilaminuria (TMAU), nota anche come &#8220;sindrome dell&#8217;odore di pesce&#8221;, \u00e8 un disordine metabolico che comporta l&#8217;emissione di un forte e sgradevole odore paragonabile a quello del pesce marcio. La sindrome \u00e8 dovuta all\u2019alterazione nel metabolismo della trimetilammina (TMA), un\u2019ammina terziaria maleodorante, normalmente ossidata dalla monoossigenasi-3 contenente la flavina (FMO3) in trimetilammina-N-ossido (TMAO), inodore. La&hellip; <a class=\"more-link\" href=\"https:\/\/portale2.unime.it\/tmaumessina\/tmau-cosa\/\">Continua a leggere <span class=\"screen-reader-text\">Cos&#8217;\u00e8 la TMAU<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-568","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cos&#039;\u00e8 la TMAU - TMAU - MESSINA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/portale2.unime.it\/tmaumessina\/tmau-cosa\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cos&#039;\u00e8 la TMAU - TMAU - MESSINA\" \/>\n<meta property=\"og:description\" content=\"La trimetilaminuria (TMAU), nota anche come &#8220;sindrome dell&#8217;odore di pesce&#8221;, \u00e8 un disordine metabolico che comporta l&#8217;emissione di un forte e sgradevole odore paragonabile a quello del pesce marcio. La sindrome \u00e8 dovuta all\u2019alterazione nel metabolismo della trimetilammina (TMA), un\u2019ammina terziaria maleodorante, normalmente ossidata dalla monoossigenasi-3 contenente la flavina (FMO3) in trimetilammina-N-ossido (TMAO), inodore. 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