{"id":619,"date":"2024-07-09T12:42:36","date_gmt":"2024-07-09T10:42:36","guid":{"rendered":"https:\/\/portale2.unime.it\/tmaumessina\/?page_id=619"},"modified":"2024-07-09T12:42:36","modified_gmt":"2024-07-09T10:42:36","slug":"what-is-the-tmau","status":"publish","type":"page","link":"https:\/\/portale2.unime.it\/tmaumessina\/en\/what-is-the-tmau\/","title":{"rendered":"What is the TMAU"},"content":{"rendered":"<p>Trimethylaminuria (<strong>TMAU<\/strong>also known as &#8220;fish odour syndrome&#8221;, is a metabolic disorder that involves the release of a strong, unpleasant smell comparable to that of rotten fish.<\/p>\n<p>The syndrome is due to impaired metabolism of trimethylamine (TMA), a malodorous tertiary amine, normally oxidized by monooxygenase-3 (FMO3) containing flavin into odorless trimethylamine-N-oxide (TMAO).<br \/>\nTrimethylamine accumulates in the body due to lack of transformation and is released externally through urine, sweat, breath, saliva and vaginal secretions.<\/p>\n<p><strong>Bibliographic Insights<\/strong><\/p>\n<ul>\n<li>Chhibber-Goel J, Gaur A, Singhal V, Parakh N, Bhargava B, Sharma A. T<strong>he complexmetabolism of trimethylamine in humans: endogenous and exogenous sources<\/strong>.\u00a0<em>Expert Rev Mol Med.<\/em>\u00a02016 Apr 29;18:e8. doi: 10.1017\/erm.2016.6.<\/li>\n<li>Fennema D, Phillips IR, Shephard EA.\u00a0<strong>Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3) \u2013 Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease<\/strong>.\u00a0<em>Drug MetabDispos<\/em>. 2016 Nov;44(11):1839-1850. Epub 2016 May 17.<\/li>\n<li>Esposito T, Varriale B, D\u2019Angelo R, Amato A, Sidoti A.\u00a0<strong>Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans<\/strong>.\u00a0<em>Horm Mol Biol Clin Investig<\/em>. 2014 Dec;20(3):99-109. doi: 10.1515\/hmbci-2014-0012.<\/li>\n<li>Motika MS, Zhang J, Zheng X, Riedler K, Cashman JR.\u00a0<strong>Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19321370\">.\u00a0<\/a><em>Mol Genet Metab<\/em>. 2009 Jun;97(2):128-35. doi: 10.1016\/j.ymgme.2009.02.006.<\/li>\n<li>D\u2019Angelo R, Esposito T, Calabr\u00f2 M, Rinaldi C, Robledo R, Varriale B, Sidoti A.<strong>\u00a0FMO3 allelicvariants in Sicilian and Sardinianpopulations: trimethylaminuria and absence of fish-like body odor<\/strong>.\u00a0<em>Gene<\/em>. 2013 Feb 25;515(2):410-5. doi: 10.1016\/j.gene.2012.12.047<\/li>\n<li>D\u2019Angelo R, Scimone C, Esposito T, Bruschetta D, Rinaldi C, Ruggeri A, Sidoti A.\u00a0<strong>Fish odor syndrome (trimethylaminuria) supporting the possible FMO3 down expression in childhood: a case report<\/strong>.\u00a0<em>J Med Case Rep<\/em>. 2014 Oct 6;8:328. doi: 10.1186\/1752-1947-8-328<\/li>\n<li>Chalmers RA, Bain MD, Michelakakis H et al.\u00a0<strong>Diagnosis and management of trimethylaminuria (FM03 deficiency) in children<\/strong>.\u00a0<em>J Inherit Metab Dis<\/em>. 2006;29(1):162-72.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Trimethylaminuria (TMAUalso known as &#8220;fish odour syndrome&#8221;, is a metabolic disorder that involves the release of a strong, unpleasant smell comparable to that of rotten fish. The syndrome is due to impaired metabolism of trimethylamine (TMA), a malodorous tertiary amine, normally oxidized by monooxygenase-3 (FMO3) containing flavin into odorless trimethylamine-N-oxide (TMAO). Trimethylamine accumulates in the&hellip; <a class=\"more-link\" href=\"https:\/\/portale2.unime.it\/tmaumessina\/en\/what-is-the-tmau\/\">Continua a leggere <span class=\"screen-reader-text\">What is the TMAU<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-619","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is the TMAU - TMAU - MESSINA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/portale2.unime.it\/tmaumessina\/en\/what-is-the-tmau\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the TMAU - TMAU - MESSINA\" \/>\n<meta property=\"og:description\" content=\"Trimethylaminuria (TMAUalso known as &#8220;fish odour syndrome&#8221;, is a metabolic disorder that involves the release of a strong, unpleasant smell comparable to that of rotten fish. The syndrome is due to impaired metabolism of trimethylamine (TMA), a malodorous tertiary amine, normally oxidized by monooxygenase-3 (FMO3) containing flavin into odorless trimethylamine-N-oxide (TMAO). 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The syndrome is due to impaired metabolism of trimethylamine (TMA), a malodorous tertiary amine, normally oxidized by monooxygenase-3 (FMO3) containing flavin into odorless trimethylamine-N-oxide (TMAO). 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