HANAIN
Tackling Influenza Viruses
by optimized hemagglutinin (HA)
and/or neuraminidase (NA) inhibitors
HANAIN project aims to contribute to the search for new inhibitors against viral proteins hemagglutinin (HA) and neuraminidase (NA) to fight influenza A viruses (IAV)
Our interdisciplinary expertise within HANAIN project
Medicinal Chemistry - synthetic approaches and structural characterization
Design, synthesis, structural characterization, and determination of drug-like properties of new small molecules. This interdisciplinary approach, with close collaboration with biologists, biochemists, and pharmacologists, ensures experimental validation of the pharmacokinetic/pharmacodynamic profiles of molecules designed for specific new molecular targets for the treatment of human diseases.
Medicinal Chemistry computational methods
Rational design of new drugs through the integration of advanced computational methodologies and artificial intelligence approaches. A multidisciplinary approach through the development of pharmacophore models, virtual screening processes, and drug design. Docking and molecular dynamics simulations, ADMET prediction, and machine learning protocols: to predict compound properties and identify new drug candidates.
Virology
Study of the molecular mechanisms regulating virus-host cell interactions, with a particular focus on herpesvirus and human retrovirus infections. The laboratory develops and optimizes innovative functional assays for the in vitro evaluation of bioactive compounds and is equipped with advanced instrumentation for molecular analyses and cellular studies.